Muscimol Reveals Long-Lasting Excitation by GABA and Random Stimulation of Spider Mechanosensory Neurons
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منابع مشابه
Random stimulation of spider mechanosensory neurons reveals long-lasting excitation by GABA and muscimol.
gamma-Aminobutyric acid type A (GABA(A)) receptor activation inhibits many primary afferent neurons by depolarization and increased membrane conductance. Deterministic (step and sinusoidal) functions are commonly used as stimuli to test such inhibition. We found that when the VS-3 mechanosensory neurons innervating the spider lyriform slit-sense organ were stimulated by randomly varying white-n...
متن کاملRandom stimulation of spider mechanosensory neurons reveals long-lasting excitation by GABA and muscimol Running Head: Excitatory actions of GABA
GABA and muscimol Running Head: Excitatory actions of GABA Keram Pfeiffer, Izabela Panek, Ulli Höger, Andrew S. French, Päivi H. Torkkeli. Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada Corresponding author: Päivi H. Torkkeli. Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 1X5, E-mail: Paivi.Torkkeli@d...
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GABA and glutamate receptors belonging to the ligand-gated chloride-channel family are primary targets of insecticides and antiparasitics, so their molecular structure, pharmacology and biophysical properties have attracted significant attention. However, little is known about the physiological roles of these channels or how they regulate neuronal excitability and animal behavior. Mechanosensor...
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GABA(A) receptors mediate mainly inhibitory effects, but there are also many examples of excitatory effects in both mammalian and invertebrate preparations. Here, we aimed to create a complete, quantitative picture of GABA(A)-mediated excitation in a mechanosensory neuron where this phenomenon has been well established. We used muscimol to activate GABA(A) receptors in spider VS-3 neurons and m...
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